Use of Atomic Spectrometry in Pharmaceutical Analysis

Use of Atomic Spectrometry in Pharmaceutical Analysis Jie Pan Introduction Pharmaceutical analysis is a critical issue for human beings, not only to verify the effectiveness of drugs, but also for the safety issues. The toxicity of various elements has been well studied and documented for many years. There are many ways to prove effective elements or compounds in drugs. For more than 100 years, the main focus on standard for testing pharmaceuticals elements has been the Heavy Elements.[1] However, there is no clear definition of heavy elements has showed authority. Most of the concern regarding elements in pharmaceuticals was associated with following elements such as: antimony(Sb), arsenic(As), Cadmium(Cd), copper(Cu), iron(Fe), lead(Pb) and zinc(Zn). The purpose in detecting pharmaceutical materials is not just for drug products, the active pharmaceutical ingredients(API’s), raw material and intermediates for metals and metalloids also very important for analysis of drugs. For these reasons, atomic spectroscopy has been developed as one of the most powerful tool for detecting metals and metalloids in drugs.[2] Atomic Spectroscopy techniques Atomic spectroscopy involving the measurements of the optical properties of free atoms. An atomization source is a system for generating atomic vapor from a sample. Classification of atomic method is depends on the source: flame atomic absorption spectroscopy(FAAS), graphite furnace atomic absorption spectroscopy(GFAAS), inductively coupled plasma-atomic emission spectroscopy(ICP-AES), direct-current argon plasma, electric arc and electric spark and inductively coupled plasma-mass spectroscopy(ICP-MS). Most common techniques of atomic spectroscopy are FAAS and GFAAS, which based on the Beer-Lambert Law. FAAS is considered to be less sensitive technique than GFAAS, with FAAS the sensitivities in the range of low parts per million(ppm, w/w), requiring milliliter quantities, while GFAAS is capable of low parts per billion(ppb. w/w) with requiring microliter quantities of sample. FAAS is considered the one with less-expensive and also easier skill level for an analyst as well as less time consuming when compared with GFAAS. Regardless of the technique, both FAAS and GFAAS require the use of a hollow cathode (HCL) or electrodeless discharge lamp (EDC) for each radiation source.[3] ICP-AES and ICP-MS have seen greater use within the pharmaceutical industry in more recent years. Both of the techniques can be applied for variety of sample types and capable of rapid, multi-element analyses. ICP-MS offering much greater sensitivity, which down to parts per trillion(ppt) than ICP-AES-pm to ppb, however, has more potential spectral interferences. Atomic absorption spectroscopy (AAS) Atomic absorption spectroscopy (AAS) is based on absorption of radiation by atoms. Main components included for AAS are: light source, sample holder, wavelength selector and detector. HCL (hollow cathode lamp) is the most common source, which applied for atomic absorption measurement.[4] Daryoush Afzali et. al. applied this technique on the detecting of palladium. Palladium is attracting a lot of attention in various fields including industry, technology and medicine. However, the long-term exposure to palladium may affect the human health. Therefore, it is our task to trace the residue of palladium, which is quite meaningful. A method for preconcentration of palladium on modified multi-walled carbon nanotubes columns has been developed. Palladium analysis requires analytical methods of high sensitivity, selectivity, and the control of interference effects. Previous research used GFAAS and ICP-MS to detect palladium, however, the mainly drawback is solvent extraction methods such as emulsion formation, different extracting efficiencies, and low sensitivity. Daryoush Afzali et. al. focused on repairing conventional solvent extraction methods for isolating environmental pollutants with solid phase extraction (SPE) techniques, which applied prior to spectrometric determination. Compared with liquid–liquid extraction, SPE utilizing solid so rbents are simpler and faster, reduce organic solvent consumption and yield higher enrichment factors. Different solid phase extractors such as Amberlite XAD resins, polyurethane foam, activated carbon, and silica gel with chelating groups have been the most widely used collectors. Carbon nanotubes (CNTs) have been chosen as solid phase extractor because of its unique thermal, mechanical, electronic, and chemical properties. The extremely large surface area and the unique tubular structure make CNTs a promising adsorbent material. The modified method using multi-walled carbon nanotubes (MWCNTs), were oxidized with concentrated HNO3 and then modified with 5-(40-dimethylamino benzyliden)-rhodanine. Following with using as a solid sorbent for preconcentration of Pd(II) ions. The effects of experimental parameters, including pH of the sample solution, sample flow rate, eluent flow rate, and eluent concentration were investigated. The procedure offers a useful, rapid, and reliable enrich ment technique for preconcentration of Pd(II) in various samples. Under the optimum condition, palladium in aqueous samples was concentrated to about 200-fold.[5] ICP-AES and ICP-MS Inductively coupled plasma utilizes an argon plasma to excite and ionize elemental species, which is the most important feature of argon ICP plasma is the temperature can be achieved around 6000-10000 K. The ions formed by the ICP discharge are typically positive ions, M+ or M2+, therefore, elements that prefer to form negative ions such as Cl, I, F, etc., are very difficult to determine via ICP-AES. Samples are aspirated into the plasma by means of a nebulizer, which generates small droplets that pass through a spray chamber and then through the center tube of a concentric torch. Desolvation, vaporization, atomization and ionization of the sample occur in the high temperatures of the plasma, and the collisions of the ions and electrons of the argon plasma ionize and excite the analyte atoms. As the ions generated within the plasma pass into the mass spectrometer, the ions are separated in the magnetic field according to their mass-to-charge ratio (m/z). Due to the heat of the plasma , the ionic components is reduced, the mass range for ICP-MS typically covers from 6 to 240 atomic mass units (amu). Therefore, offers an advantage over ICP-AESà £Ã¢â€š ¬Ã¢â‚¬Å¡ The nature of interferences in ICP-MS is typically due to the formation of multiply charged ions, oxides and polyatomic isobaric interferences formed in the plasma.[2] Multi-elements detection in pharmaceutical analysis helps improve efficiency on analyzing and also reduce the sample amount. Its not only save our time, but also increase accuracy and explore more mechanism details in pharmacy. In a series of papers, by using ICP-AES to study the effects of aging. Tohno et al. measured multi-elements Ca, Mg, P and S in the four human cardiac valves showed that Ca and P accumulated most in the aortic valve, about 12–19 fold higher than in the tricuspid valve, which showed the least accumulation.[6-7] Lin and Jiang et. al. used slurry sampling of hypertensive drug tablets to introduce a dry aerosol for ETV-ICP-MS measurement of Cd, Cr, Mo, Pb, Pd and Pt. Electrothermal vaporization (ETV) is one of alternative technique to solution nebulization, which is coupled with ICP-MS. This new combination allows the possibility to perform direct analysis of solids. Most of the traditional techniques require sample pretreatment, such as acid digestion and d ry ashing. These pretreatment procedures bring issues such as time consuming, with the consequent risk of sample contamination and analyte loss. In this situation, Lin and Jiang et. al. proposed USS-ETV-ICP-MS as an alternative technique for the direct determination of Cr, Mo, Pd, Cd, Pt and Pb in three antihypertensive tablets (Cozaar, Norvasc and Bisoprolol). The innovative method by coupling electrothermal vaporization with ICP-MS provides a simple way to determine Cr, Mo, Pd, Cd, Pt and Pb in drug tablets without complicated sample pretreatment. By these means, the method precision was increased to 5% RSD (25% for Pt). Moreover, It has been demonstrated to be effective in alleviating various spectral interferences in ICP-MS analysis.[8] Conclusion For the patient safety perspectives, the need for the analysis of elements in pharmaceuticals to qualify product is becoming more important. Nowadays, since the variety of instrumental techniques, such as flame and graphite furnace AA, which is mature and traditional to newer technologies, ICP-AES and ICP-MS, make it possible to monitor multi-elements at same time with the concentration from sub-ppb’s to percent’s.[9-10] As we mentioned above, the selection of sample pretreatment is the key to the success of an analysis. The elimination of pretreatment of sample can be achieved now, which avoid risk of sample contamination and analyte loss. In the future, there is no doubt that detection limit will be reduced and the sensitivity of instrument will be increase. More sensitive technique such as ICP-MS and also modified ICP-MS will play an important role. Easier skill and low expenses of this technique should be developed. Only various techniques which can deal with diffic ult sample matrices and low limits of detection can help us to meet the challenges to address both product safety and product quality issues.[2, 11] References [1] A. Taylor, S. Branch, D. Halls, M. Patriarca, M. White, Journal of analytical atomic spectrometry 2002, 17, 414-455. [2] N. Lewen, Journal of pharmaceutical and biomedical analysis 2011, 55, 653-661. [3] M. Ahmed, M. A. Qadir, M. Q. Hussain, American Journal of Analytical Chemistry 2014, 05, 674-680. [4] J. S, V. K, A. S, Int. J. Res. Pharm. Chem. 2012, 2, 146-163. [5] D. Afzali, R. Jamshidi, S. Ghaseminezhad, Z. Afzali, Arabian Journal of Chemistry 2012, 5, 461-466. [6] Y. Tohno, S. Tohno, T. Minami, Y. Moriwake, F. Nishiwaki, K. Hashimoto, H. Yamamoto, Biological Trace Element Research 2000, 77, 107. [7] Y. Tohno, Y. Takano, S. Tohno, Y. Moriwake, T. Minami, F. Nishiwaki, M. Yamada, M. Utsumi, K. Yuri, Biol. Trace Elem. Res. 2000, 77, 119. [8] M.-L. Lin, S.-J. Jiang, Journal of analytical atomic spectrometry 2011, 26, 1813. [9] A. Taylor, M. P. Day, S. Hill, J. Marshall, M. Patriarca, M. White, Journal of analytical atomic spectrometry 2013, 28, 425. [10] A. Taylor, M. P. Day, J. Marshall, M. Patriarca, M. White, Journal of analytical atomic spectrometry 2012, 27, 537. [11] N. H. Bings, J. O. Orlandini von Niessen, J. N. Schaper, Spectrochimica Acta Part B: Atomic Spectroscopy 2014, 100, 14-37.

Does Socrates see himself as the most important teacher in the city? :: Essays Papers

Does Socrates see himself as the most important teacher in the city? In Plato’s Apology of Socrates, Socrates has to defend himself to the city of Athens. The city of Athens is at odds with Socrates’ philosophy; it contradicted several Athenian beliefs. The city believed that Socrates was an atheist, that he was responsible for corrupting the youth, and that he made the weaker argument the stronger. Socrates believed that he was the most important teacher in the city therefore he continued to defend his actions and beliefs even when his life was on the line. He saw himself as the most important teacher after his visit to the oracle. He believed it was his mission to change the Athenians viewpoints, and he was willing to die for what he believed in. Socrates forced the Athenians to think and to question how they lived their lives. He was a great philosophizer and he knew how important he was to the city. The city did not share Socrates own view of himself as the most important teacher. They believed his philosophies were evil and they were willing to put him to death for his ideas. In Socrates’ first defense, he uses the story of the Delphic oracle. According to Socrates, the oracle once declared that no one was wiser than Socrates. At first Socrates thought the oracle to be wrong so he began to obtain evidence by conversing with wise people in order to refute the oracle: He examined the politicians, poets, and artisans and found that they were almost completely ignorant (except for the artisans, who at least knew well their own areas of expertise), and that all thought they knew things, especially â€Å"the greatest things,† but in fact they did not know them. Since Socrates was at least aware of his own ignorance, he ranked himself above them in wisdom. (18) Thus Socrates began to believe that he was the wisest person in the city. The oracle was a turning point in his life. Instead of focusing on astronomical and physical studies, he began to concern himself with moral and political opinions: â€Å"this turn to the examination of opinions brought Socrates into conflict with the city as such, for his doubt of the worth of generally accepted opinions was also a challenge to the most authoritative opinions, those which concern the city’s gods and the city’s laws†¦Ã¢â‚¬ (18). The fact that Socrates knew he was the wisest and that he began to concern himself with philosophies of the city shows that he saw himself as the most important teacher in the city.

Marketing in the business world.

IntroductionWith competition so intense, many businesses is forced to find innovative ways to increase the quality and sales of their products, from manufacturing to inventory to marketing, using advance technology that is now readily available for anyone willing to adopt it. This is exactly why over the last few years’ information technology has taken a firm grasp and continues to gain momentum. The business world is competitive and everyday presents new and difficult challenges.   Companies must rely on the most effective marketing and sales strategy in order to remain in front of their competition.   In the business world, most companies nowadays use the web technology and Internet to ensure these goals are both surpassed and met. This paper discusses in detail the approach of companies to marketing in the business world.Marketing in the Business WorldIn the business world, effective marketing becomes increasingly tied up with the Internet and other electronic media, ma king the most of the Internet and other new technologies is important to a business success — from the brand image portrayed on its Web site to the development, maintenance and enhancement of customer relationships. In these increasingly uncertain and cynical times, marketing in the business world unpicks the challenges of e-marketing for many types of business.The Web is very information concentrated environment. Extensive amounts of information can be integrated, collected, presented, processed, and accessed through the Web by both consumers and marketers. Marketers now can track comprehensive information for all consumer interactions, not just select examples. On the other hand, soft market qualities, such as reliability and reputation, maybe more difficult to evaluate and gather.Consumers can increase more market information for criteria evaluation; however possible problems of information excess may increase recognised searching costs (Head et al. 2000). Marketers may pr ovide tools to facilitate consumer information collection, but may have to restructure their marketing strategies since competitors can also gather market information and match price differences.Peterson et al. (1997) argues that the Web will have major effect on communication, will influence transactions, but will have no effect on distribution unless the good is based on digital assets. Businesses, which consider the Web as a marketing instrument, primarily utilise it as a communication means to take advantage of its benefits in lower costs, personalisation, interactivity, digitisation, automation, and constant communication. Most businesses who do not currently sell their products/services through their web sites hold this view. Many businesses create their site to foster better communication and public relations. Consumers can obtain corporate information, and may be encouraged to subscribe to customised electronic flyers/newsletters.Mahajan and Wind (1989) explained that Web is a market discontinuity. Companies, which deal with the Web channel as a promising new marketplace that helps a complete range of interaction, may find that it co competes and -exists with traditional markets. New importance must be identified and valued by consumers to compete and participate with existing market channels. For instance, customers must value the ease and flexibility of using Web. Companies need to deal with market positions/boundaries to fit the new value with customers' needs, and look for proper business models in order to achieve these needs. Customer base will be new and existing groups with unique value principle, which may be difficult to attain through traditional channels.In addition to using the Web as a marketing tool and for information searching, consumers can increase their market power through high involvement in business processes and virtual communities. These are new Web-centered strategies, which are restricted in traditional markets by fixed physi cal assets and slow transfer of information (Werbach 2000). Some researchers have noted the commercial effects of Web groups (Kozinets 1999). Communication convenience allows consumers to form communities outside their traditional work or family groups.Such communities accumulate information or knowledge by learning from the experiences of individual community members. Information collection costs and times are often reduced for individuals within a community. Opinions from other consumers are often more valued than messages from marketers, especially in a Web market, where trust is critical and more difficult to build. Not only do groups have a strong effect on purchasers' decision-making, but they may also affect market variables such as products and prices.For example, stocks that capture the attention of participants in chat rooms can move noticeably in price (Bruce 1997). The Web, as an interactive marketplace, also gives the consumer data selection and personalisation power. C ustomers can select information of interest and personalise presentation forms for their own use. Personalized Web pages, which can be constructed fairly easily, increase customer power. Customers on the Web have greater control over what they view and examine. They can select their own path through the information network, process the data, or initiate communication with marketers.There is a general consensus that the industrial organisational impacts of using e-commerce as marketing tool will reflect two developments: 1) the expansion of relevant geographical markets, and 2) increased competition in those markets. The two changes are related (Globerman et al. 2001). However, E-commerce businesses are characterised by high market capitalisations, which are reflected in the perception of their business models by investors (Venkatraman 2000). Primarily, businesses in the Internet carry a 30% marketing budget in order to reach more customers.Specifically, as electronic commerce makes it less costly to identify beneficial transactions across a wider range of potential transactors, it should lead to an increased integration of markets that are currently segmented by high transactions costs across geographical space. In addition, geographically larger markets are ordinarily more contestable than smaller markets. In this perspective, one well-known international business professional stated that electronic commerce implies the end of borders and geography as industrial organisation constructs (Kobrin, 1995).Decision to include international buyers as part of the customer base for a business's Web site, changes must be made to the site in order to promote global consumers to buy products. Internationalising the Web site will aid in the attraction and retention of foreign users by allowing them easier access to the information and functions it presents in a standardised, more simplified manner.Most businesses lack the expertise and resources to create separate Web sit es along with the independent channels of marketing, distribution and production facilities needed for each target market they intend to enter. As a result, these businesses are expected to enter into the business world on a smaller scale, sticking to stages one and two when redesigning their Web sites with a global focus.ConclusionThe Internet has made an outstanding impact within its first decade of business use. Marketing professionals have been quick to realise the opportunities provided by the Internet. Particularly, they recognised that business could be improved by integrating the Internet with direct marketing practices such as database marketing. The challenge for information systems practitioners and professionals is to understand these opportunities with the accessible technologies in the relative constraints of an organisation.It is included that e-commerce which is driven by the exponential growth of the Web is the most common marketing practices taking advantage of the Web by utilising information technology to sell large quantities of products and to become more responsive to the individual. The role of the Internet, in particular, of the electronic commerce web sites, has been recognised as a marketing tool for attracting and maintaining customers.ReferenceBruce, C. (1997). Welcome to my parlor. Marketing Management, 5 (4), 11-24.Globerman, S., Roehl, T. and Standfird. (2001) Globalization and Electronic Commerce: Inferences from Retail Brokering. Journal of International Business Studies. Volume: 32. Issue: 4.Head, M., Archer, N.P., & Yuan, Y. (2000). World wide web navigation aid. International Journal of Human-Computer Studies, 53 (2), 301-330.Kobrin, S.J. 1995. Regional Integration in a Globally Networked Economy. Transnational Corporations, 4 (2): 15-33.Kozinets, R.V. (1999). E-tribalized marketing?: The strategic implications of virtual communities of consumption. European Management Journal, 17 (3), 252-264.Mahajan, V., & Wind, J. (1989) . Market discontinuities and strategic planning: A research agenda. Technological Forecasting and Social Change. 36 (August), 185-199.Peterson, R., Balasubramanian, S., & Bronnenberg, B.J. (1997). Exploring the implications of the internet for consumer marketing. Journal of the Academy of Marketing Science, 25 (4), 329-346.Venkatraman, N. (2000) Five steps to a dot.com strategy: How to find your footing on the Web, Sloan Management Review, 41(3), 15-28.Werbach, K. (2000). Syndication: The emerging model for business in the Internet era. Harvard Business Review 78 (3), 85-93.

Essay about Persuasive Forms of Leadership - 1063 Words

Persuasive Forms of Leadership Paper Leadership is the most discussed topic when it comes to business. There has been much research into leadership and it the effect it has on the followers. Leadership research has included various attributes that show the difference between leaders and non-leaders and the effect it has on the followers. Leadership is a process using socially acceptable behavior, including personality traits used to inspire individuals to reach a goal or objective. There have been many studies that shown individual characteristics including skills and abilities can predict leader effectiveness. This paper is designed to discuss the persuasive forms of leadership and how the persuasion can facilitate change.†¦show more content†¦Leaders need to recognize that certain motivators may not always be the best motivators. Considering that some motives may be complex, they are usually a result of some initiative that an individual may have brought about based on their personality or experience. One way to persuade followers or employees is to offer them financial incentives to increase output and profits. However, the consideration of financial incentives should also consider the leaders behavior on the employees which may have influenced the employees to increase output and profits. A transactional leader focuses on tasks and behaviors rather than relationships. Traits and behaviors influence effectiveness of the followers not necessarily the motivating factors associated with the task, such as financial (Derue, 2011). Values of the individual need to be considered when considering which motivators should be used. Persuasive and Effective Leaders When you consider Fiedler’s Contingency Theory, there are two types of leaders who are effective in different types of situations. 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